The Paradox of Feline Coronavirus Pathogenesis: A Review
Luciana Wanderley Myrrha, Fernanda Miquelitto Figueira Silva, Ethel Fernandes de Oliveira Peternelli, Abelardo Silva Junior, Maurício Resende, Márcia Rogéria de Almeida
Advances in Virology, 2011. DOI 10.1155/2011/109849. Licence: Creative Commons Attribution License (open access).
Abstract
Feline coronavirus (FCoV) is an enveloped single-stranded RNA virus, of the family Coronaviridae and the order Nidovirales. FCoV is an important pathogen of wild and domestic cats and can cause a mild or apparently symptomless enteric infection, especially in kittens. FCoV is also associated with a lethal, systemic disease known as feline infectious peritonitis (FIP). Although the precise cause of FIP pathogenesis remains unclear, some hypotheses have been suggested. In this review we present results from different FCoV studies and attempt to elucidate existing theories on the pathogenesis of FCoV infection.